ABSTRACT

The time-honored classification of leukemias and lymphomas by standard light microscopy of blood and bone marrow, together with cytochemical stains, has been greatly facilitated by the advent of immunophenotyping of fluorochromelabeled monoclonal antibodies to stain cells to be analyzed by flow cytometry. Advances in molecular genetics have also played a crucial role. However, the present discussion will be confined to major immunophenotyping findings in the more commonly diagnosed lymphoid neoplasms. The reader should refer to the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues, 4th ed., issued by the World Health Organization, an international agency for research on cancer, for further details.