ABSTRACT
Immune function depends on a balance between free radicals and the antioxidant status of the body. Exposure of healthy adults to high levels of oxidants leads to diminished immune responses. Exposure to low levels of dietary antioxidants also decreases immune responses such as delayed type hypersensitivity. There is increased oxidative stress and immune dysfunction in rheumatoid arthritis, aging, and cigarette smoking. This leads to damage to lipids and other cellular components by free radicals. Antioxidant status is reduced in arthritic patients and smokers compared with controls. Thus, supplemental antioxidants are useful in diminishing oxidative stress and improving immune function. Increased levels of antioxidants may be needed for elderly individuals to maintain delayed-type hypersensitivity responses.
