ABSTRACT
This article will cover properties inherent to nanoparticles as well as methods for their production and use. In their study, absolute bioavailability of the nanoparticle formulation was 77% higher than a similar formulation consisting of micro-particles. It is reported that nanoparticles possess improved dissolution and bioavailability when delivered orally. The milling apparatus consists of a milling chamber, milling shaft, and recirculation feed. The drug of interest is dissolved in the organic phase at which time the drug diffuses into the aqueous droplets where it precipitates. It is ideal that the lyophilization temperature be below and near the Tg 0 for the given system for optimum solvent removal and stability. Dynamic Light Scattering (DLS) or photon correlation spectroscopy Particle size distribution measurements using DLS requires dilute dispersions of particles that are less than 6mm in diameter. DLS is well suited for measuring nanoparticles because it takes advantage of Brownian motion, which is unique to colloidal particles.
