ABSTRACT
As noted in Chapter 25, enzymatic lipid peroxidation is characterized by the involvement of
enzymes at different stages of lipid peroxidation and not only at the initiation. Furthermore,
the products (leukotrienes, prostaglandins, etc.), which are selectively formed in the reactions
catalyzed by lipoxygenases (LOXs) and prostaglandin H synthases, display important physio-
logical and pathophysiological properties, while the products of nonenzymatic lipid perox-
idation are mostly the damaging agents. In this chapter, we will consider the mechanisms
of lipid peroxidation and free radical production catalyzed by LOXs and prostaglandin
H synthases.
