chapter  28
16 Pages

DNA Oxidative Damage

The amount of work dedicated to the study of DNA oxidative damage is large enough to

successfully compete with the studies on lipid peroxidation (Chapters 25 and 26). DNA

molecule is an easy target for the attack of many oxidants including free radicals, transition

metal ions, and active oxygen and nitrogen species. On the other hand, specific effective

repairing mechanisms protect nucleic acids from oxidative damage. This chapter is dedicated

to the consideration of mechanisms of free radical damage and repairing DNA.