ABSTRACT

Conditioning Brain Function...................................................................191 15.3 Prevention of Cerebral Oxidative Injury by SMS in Rat .......................191 15.4 Relationship between In Vitro and In Vivo Antioxidant Activity of

TCM.........................................................................................................193 15.5 SMS Modulates Cellular Antioxidant Defense Potential .......................194 15.6 Conclusion ...............................................................................................195 Acknowledgments .............................................................................................196 References .........................................................................................................196

Oxidative stress is now accepted as a ubiquitous condition involved in the initiation and progression of many diseases. Free radicals also play a critical role in brain injury caused by stroke or ischemia condition and, thus, radical-scavenging medicines such as Edaravone are clinically used to prevent progression of brain damage after the injury. However, the process leading to neuronal cell death is associated with multiple disturbances of cellular reaction such as cell signaling and damage repair. Therefore, composite therapy will be more appropriate to