ABSTRACT
References ...............................................................................................328
Activation of nitric oxide synthase (NOS) isoforms can result in a remarkable diversity of cellular effects (1, 2). These effects are broadly classified as being guanylate cyclase/cyclic GMP (cGMP)-dependent and cGMP-independent. cGMP-independent effects can be cytotoxic/antimicrobial, such as those involving tyrosine nitration through peroxynitrite or nitrite, or they can involve thiol S-nitrosylation (2).
