Nitric Oxide Controls Cell Respiration by Reacting with Mitochondrial Complex IV

NO and Mitochondria ................................................................................3 1.3 The Fast-Responding Mitochondrial Target of NO is

Cytochrome c Oxidase ..............................................................................4 1.4 Two Mechanisms of the Inhibition of CcOX by NO ...............................8 1.5 The Reaction of NO with Oxidized CuB Yields the Nitrite-Inhibited

CcOX, Rapidly Recovering Function ........................................................9 1.6 The Reaction of NO with the Fully Reduced (R) or the

Half Reduced (E) Species Yields the Nitrosyl-Inhibited CcOX, Slowly Recovering Function ...................................................................10

1.7 The Reaction between NO and CcOX in Turnover ................................12 1.8 Experimental Designs ..............................................................................17 1.9 Persistence of NO in the Mitochondrion ................................................20 1.10 Acknowledgments ....................................................................................22