ABSTRACT
Liquid chromatography and molecular imprinting have been tightly interlaced from the very beginning. Just few years after Dickey’s paper on imprinting of silica gels with alkyl-orange dyes [1], Curti and Colombo [2] published another paper about the separation of racemic mixtures on silica gel columns imprinted with a single enantiomer. The rebirth of the noncovalent molecular imprinting technique in the early 1980s by Mosbach and coworkers [3] (noncovalent approach, see this book, Chapter 3) and Wul¡ and Sarhan (covalent approach, see this book, Chapter 4) was marked by papersmainly concerning the use of high pressure liquid chromatography to characterize the presence of an imprinting e¡ect [4,5].
