ABSTRACT
It is generally recognized that the surface of material is different from the bulk of the same material. However, there are few parameters that could be used to describe differences between bulk and surface properties of a material. With many surface phenomena, such as adsorption of proteins on polymer surfaces, a polymer surface is often treated as if the surface is a rigid and imperturbable plane on which proteins are adsorbed. The configuration of a protein that is adsorbed is one of the most important issues in dealing with the biocompatibility of polymers. However, little attention has been paid to the responsive movement of polymer segments to accommodate a protein in a specific configuration, such as a hydrophilic or hydrophobic moiety facing the surface. The responsive movement of polymer segments can be treated as perturbation of the surface by the contacting phase, which contains a certain kind of protein in the case of the protein adsorption.
