ABSTRACT
Accurately predicting human toxicity based on data obtained using experimental systems may be one of the most challenging goals in toxicology. In classical toxicology, these experimental systems are whole-animal systems involving several mammalian species. More recently, mecha nistically based toxicity assays are being developed that use tools in cell and molecular biology. It is now a common belief that with a thorough understanding of the mode of action of a toxicant, one can more accurately predict its human toxicity at physiologically relevant doses and exposure regiments.
