ABSTRACT
In order to assess properties of solutions it is necessary first to be able to produce them. For this reason, it is of importance to determine the solubility of a compound in aqueous media.
2 .1 AQUEOUS SOLUBILITY OF NON-IONIZED DRUGS
In the following, solubility of substances that do not ionize in solution will be treated first. The solubility of a compound should be expressed as grams (or moles) of solute per 1000 g of solvent, not per 1000 mL of solution. It is often difficult to determine solubility with small amounts of drug substance, particularly if the drug is quite soluble. However, if it is quite soluble, then many problems with formulation may not exist, other than the fact that the drug may be hygroscopic, and in such a case when hygroscopicity is determined (and this is described in a later chapter), the solubility may be deduced.
