chapter  7
20 Pages

The Cardiac Toxicology of Organophosphorus Agents

The phannacology of the cholinesterase inhibitors as it relates to the heart has been largely attributed to the actions of excess acetylcholine and it has been extensively reviewed (Higgins et al., 1973; Levy and Martin, 1979). These earlier reviews offer a rigorous discussion of the actions of acetylcholine on cardiac function and set a stage for this review on organophosphorous agents.