ABSTRACT
Seoul virus (SEOV) is a negative-sense ssRNA virus in the genus Hantavirus, family Bunyaviridae. It is grouped together with Amur virus (AMRV), Dobrava virus (DOBV), and Hantaan virus (HNTV), all of which are transmitted by Murinae rodents (Old World mice and rats), and are responsible for hemorrhagicfever with renal syndrome (HFRS) in humans throughout Europe and Asia (Figure 63.1) [1-4]. In addition, it is closely related to Puumala virus (PUUV) and Tula virus (TULV), which are transmitted by Arvicolinae rodents (voles) and cause HFRS in Europe. By contrast, other signicant human pathogenic hantaviruses, for example, Andes virus (ANDV), Black Creek Canal virus (BCCV), and Sin Nombre virus (SNV), are transmitted by Sigmodontinae rodents (New World mice and rats) and are causative agents for hantavirus cardiopulmonary syndrome (HCPS) in Americas (Figure 63.1) [5-9].
