ABSTRACT
Introduction Involuntary childlessness affects approximately 15% of all couples but the majority of cases are due to inability to conceive (infertility) and only 1-2% are due to recurrent miscarriage defined as three or more consecutive losses of intrauterine pregnancies before gestational week 22. Much research into the causes of infertility and their management have been performed, and a series of treatments with proven efficacy have been introduced into widespread clinical use. Research regarding the management of couples with recurrent miscarriage has been rarer and often of low-quality, which is partly due to the lower prevalence of recurrent miscarriage, the limited interest of pharmaceutical companies to support research in recurrent miscarriage treatment and the more complex, multifactorial background of RM compared with infertility.1 Which investigations and treatments should be undertaken in recurrent miscarriage therefore remain a matter of great controversy.
