ABSTRACT
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ABSTRACT The most disappointing aspect of solid-state NMR spectroscopy is the requirement of a large amount of sample and/or a long acquisition time. Some of the most interesting biomolecules, such as membrane proteins and RNA, are not abundantly available and also do not withstand long high power solid-state NMR experiments. Therefore, there is a considerable interest in developing methods to increase the sensitivity of this powerful tool. To accomplish this goal, a number of proton-detection techniques have recently been reported. In this chapter, we address the need for higher sensitivity experiments, discuss the difficulties in designing such techniques, and explain the merits of different types of proton-detection methods.
