ABSTRACT

DNA ................................................................................................154 6.4 Structural basis of DNA polymerization ...............................................155

6.4.1 Crystal structure overview ..........................................................155 6.4.2 Structural insights to reduced fidelity of HIV-1 RT ................157 6.4.3 Structural insights from bypass DNA polymerases................158

6.5 Inhibition of viral DNA polymerases by substrate analogs ...............159 6.6 Conclusion...................................................................................................160 References.............................................................................................................161