ABSTRACT
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4.1 Introduction The nonenzymatic replication of oligonucleotides has been extensively studied for many years because it models the type of reaction thought to have been important in the origin of life, particularly those that invoke the RNA world.1,2 Much of this work has focused on template-directed polymerization. For the most part, these studies have employed activated mononucleotides in the form of triphosphate as substrate,1,3 but a few have used short activated oligonucleotides.4
