ABSTRACT

As Tatterson [52] notes, "there is much more volume on scaleup than is typically recognized. This is one feature of scaleup that causes more difficulty than anything else." For disperse systems, a further mechanistic implication of the changing volume and surface area ratios is that particle size reduction (or droplet breakage) is more likely to be the dominant process on a small scale, whereas aggregation (or coalescence) is more likely to be the dominant process on a large scale [52].