ABSTRACT
Skull base tumors are rare, and the site of origin may be difficult to determine as often there is involvement of multiple skull base compartments with variable effects on important neurovascular structures (1). Infiltrating skull base cancers may arise from the nasopharynx, paranasal sinuses, major and minor salivary glands, and skin. Treatment of nasopharyngeal cancers has been the subject of excellent recent reviews (2,3), and will not be addressed in this chapter. We will focus our discussion on chemotherapy for sinonasal cancers since they are a common malignancy that involve or invade the cranial base.
