ABSTRACT
Chordomas and chondrosarcomas of the skull base can present formidable challenges to effective treatment. These challenges include the relative inaccessibility of the skull base, tumor involvement of critical neural and vascular structures, a tendency to recur locally, andpossiblemetastatic dissemination. Despite such challenges, the combination of aggressive skull base surgical resection and high-dose radiation can cure almost all low-grade chondrosarcomas and provide meaningful intervals of disease control of both chordomas and high-grade chondrosarcomas.
