ABSTRACT
The chemical cleaning agents discussed in Chapter 2 are very important for cleaning performance. However, equally important is the cleaning method used. Cleaning methods are usually differentiated based on the extent of disassembly required for the cleaned equipment and on the method of contacting the chemical cleaning agent with the surface to be cleaned. This chapter will cover different cleaning methods as well as some key engineering factors in the design of equipment to facilitate ease of cleaning. Knowing of the limitations of cleaning methods is important to facilitate appropriate controls to help assure a validated or validatable cleaning process. Cleaning application methods discussed in this chapter include the following:
CIP (clean-in-place) Agitated immersion
Static immersion (soaking) Automated parts washing
Ultrasonic cleaning
High pressure spraying
Manual cleaning
The features, advantages, and disadvantages of each of these methods will be covered separately.
