ABSTRACT
INTRODUCTION Isothermal microcalorimetry (IMC) offers an attractive approach to stress testing because its measured parameter (heat change) is a near universal accompaniment to chemical or physical change. It is also nondiscriminating in terms of sample physical form (meaning that solids, liquids, or semi-solid materials can be analyzed directly) and the local environment in the sample ampoule is easily controlled (so it is easy to match classical stress conditions). Calorimetry is, therefore, ubiquitous and usable, in principle, from system to system and avoids the signifi - cant drawback of having to design assays specifi c to individual molecules. Furthermore, it can be a single, common thread running through compound development, in systems of increasing complexity.
