ABSTRACT
In this chapter, we present a unified synthesis method that combines defect-tolerant architectural synthesis with droplet-routing-aware physical design [50,51]. Droplet routability, defined as the ease with which droplet pathways can be determined, is estimated and integrated in the synthesis flow. The proposed approach allows architectural-level design choices and droplet-routing-aware physical design decisions to be made simultaneously. Presynthesis and postsynthesis defect tolerance are also incorporated in the synthesis tool. We use the dilution steps of a protein assay as a case study to evaluate the proposed synthesis method.
