Coarse-Grained Models for Nucleic Acids and Large Nucleoprotein Assemblies

Acknowledgment ........................................................................................................................... 232 References ...................................................................................................................................... 232

There are a variety of reasons for using coarse-grained (CG) models. There is, of course, the obvious advantage of computational ef ciency: if a CG model can capture the most important features of the structure, then CG simulations can treat larger systems and longer time scales than are accessible for all-atom simulations. In most such cases, one would prefer to use an all-atom description, but the computational demand precludes doing so. Other authors in this volume consider such cases.