ABSTRACT
INTRODUCTION Compacted tablets are produced from granulations or powder mixtures, made by the
following general techniques: wet granulation or wet massing combined with tray drying or
fluid bed drying, wet granulation and drying all in one step, dry granulation by roller
compaction or slugging, and dry blending (direct compaction). Of these, the oldest is the
classic wet granulation and drying technique in two steps using tray drying. In spite of
enormous improvements in wet granulation techniques (high-shear granulation, fluid bed
granulation, extrusion granulation, continuous granulation, and all-in-one granulation), tablet
production by direct compaction has increased steadily over the years because it offers economic advantages through its elimination of the wet granulation and drying steps.
