ABSTRACT
Drug metabolism, drug disposition, and drug-body interactions are complex traits determined by many genetic and environmental factors. The genetic factors are usually studied in an experimental cross (backcross, F2, or advanced intercross lines) of animal models, such as the mouse, through quantitative trait locus (QTL) analysis. Although QTL mapping shows an advantage of detecting novel key genes involved in various metabolic pathways of drug interactions, this approach has proven to have low-resolution characterization of genes that underlie a complex trait. Recently, it is suggested that haplotype analysis with genome-wide typed single nucleotide polymorphisms (SNPs) in controlled crosses may be useful for fine mapping of complex traits including those related to drug response (Park et al., 2003; Wiltshire et al., 2003; Wang et al., 2004; Yalcin et al., 2004, 2005; Cuppen, 2005; Payseur et al., 2007).
