ABSTRACT

In this chapter we will study the method based on inverse-normal p-values (MINP), in which the test statistic at the kth stage Tk is a linear combination of the weighted inverse-normal of the stagewise p-values. The weight can be …xed or a function of information time. MINP can be viewed as a general method including the group sequential method, the Lan-DeMets error-spending method, the Lehmacher-Wassmer method, the Fisher-Shen self-design method, and the Cui-Hung-Wang SSR method as special cases.

5.1 Method with Linear Combination of Z-Scores