ABSTRACT
Uncompetitive Inhibitors.............................................................................225 14.5 Mechanism-Based CAO Inhibitors .............................................................228 14.6 Designing and Signicance of Amine Oxidase Inhibitors ......................... 235 Acknowledgments .................................................................................................. 237
Historically, two key points have guided the development of inhibitors of CAOs, namely the two prosthetic groups of these enzymes: the organic active carbonyl cofactor responsible for oxidative deamination of primary amine substrates and the active site copper (cupric ion). Indeed, most inhibitors of the enzymes act at one or the other of these two active-site entities. It has long been known that the enzymes are inhibited by carbonyl reagents such as hydrazine and semicarbazide.
