chapter  11
1Chapter 1 Optical Imaging of Neuronal Activity in the Cerebellar Cortex Using Neutral Red
Pages 26

Fiber Stimulation .......................................................................................... 321 11.6 Examples of Using Neutral Red to Study Normal and Abnormal

Processes ....................................................................................................... 325 11.6.1 Parasagittal Organization of the Cerebellar Cortex ......................... 325 11.6.2 Optical Imaging of Plasticity at the Parallel Fiber-Purkinje

Cell Synapse ..................................................................................... 327 11.6.3 Spreading Acidication and Depression .......................................... 328

11.7 Discussion and Future Directions ................................................................. 330 References .............................................................................................................. 332

Over the last decade our laboratory has developed and used optical imaging techniques to monitor neuronal activity in the cerebellar cortex in vivo. These techniques include the use of voltage sensitive dyes,1-3 neutral red,4,5 avoprotein autouorescence,6,7 and

Ca++ imaging.7 Optical imaging has allowed us to address a spectrum of questions about both normal and abnormal cerebellar cortical physiology.