ABSTRACT
Acknowledgments .................................................................................................. 388 References .............................................................................................................. 388
Intraoperative optical intrinsic signal imaging (iOIS) provides an unparalleled opportunity to examine the basic physiology of the functioning human brain. At the same time, iOIS poses challenges for acquisition, analysis, and interpretation that are over and above those encountered in any other intact in vivo brain mapping. This may explain why, despite a profusion of optical imaging papers in the basic neuroscience literature, there have been relatively few publications on intraoperative optical imaging since its advent in 1992. Nevertheless, the clinical and research utility of this tool is considerable, and technological advances have made it even more so.
