ABSTRACT
Laboratory animal science is concerned with standardization of all the factors that may have an impact on animals and, consequently, on experimental results, as nicely presented half a century ago by Biggers, McLaren, and Michie (1958). Unnecessarily large variation is the enemy of scientists; hence, all approaches and methods to control variation should be utilized. This is a key element in animal experiments with the aim to operate with best practice and with relatively low numbers of animals.
