ABSTRACT
In this chapter we will address how we can numerically compute from observed data the parameters and other quantities, discussed in the previous chapter. In real life we do not get plasma concentration data as polyexponential functions. Instead we determine a series of time points (relative to dosing) at which blood samples are taken and plasma concentrations are measured. The quality of those data, as estimates of the true plasma concentration profile, depends on our choice of time points. An inappropriate choice may make us miss the peak concentration or we may not have sampled long enough to obtain a good estimate of the terminal elimination rate.
