Significant Differential Methylation
In mammalian genomes, many of the high CG-dinucleotide content regions occur in or near the promoters of genes. The so-called CpG islands are mostly unmethylated. CpG island methylation is correlated with gene expression silencing. Aberrant methylation thus was found to be associated with many developmental disorders and cancers. Identification of differential methylation between cases and controls has implications in molecular etiology, diagnosis and therapy.