chapter  7
20 Pages

Cluster Analysis

As the number of CGI (CpG island) loci in a high throughput microarray goes up, the methylation in previously unexplored and unannotated genomic regions is measured. One way to characterize the unannotated CpG islands is to associate them with the annotated CpG islands in the microarray. The function of the unannotated CGIs and the downstream genes can be implicated from that of the associated annotated CGIs. The association is accomplished by clustering, which is the topic of this chapter.