ABSTRACT
The different enantiomers of chiral drug substances often exhibit different pharmacological and toxicological properties as well as different pharmacokinetic behavior. Thus, the safety and ef cacy of chiral pharmaceuticals are critically related to their enantiomeric purity, and therefore, the development and optimization of chiral
analytical methods is a very important eld for quality control in the pharmaceutical industry [1]. Hence, the demand for quantitative analytical techniques assessing the exact composition of a racemate or determining the enantiomeric excess (ee) of an enantiomeric pure substance is growing.
