chapter  15
42 Pages

Chapter Recent Applications in Capillary Electrochromatography

Capillary electrochromatography (CEC) is a separation technique that theoretically combines the advantages of both liquid chromatography (LC) and capillary electrophoresis (CE). Due to the presence of a stationary phase (SP) inside a capillary and the use of an electro-osmotic ow (EOF) as a driving force for the mobile phase, the user can bene t from properties, such as a high sample loading capacity, high ef ciencies, high peak capacities, and low sample and solvent consumptions [1]. Since its introduction as separation technique in the early 1970s [2], many applications have been developed in CEC. These applications nd their origin from a variety of research areas, such as environmental analysis, food and natural products analysis, industrial analysis, forensic analysis, and pharmaceutical and biomedical

analysis [3]. In the pharmaceutical domain, the separation of chiral compounds is most thoroughly studied.