ABSTRACT
Hyperthermia treatment has been demonstrated eective as a cancer therapy in recent years. Its objective is to raise the temperature of pathological tissues above cytotoxic temperatures (41°C to 45°C) without overexposing healthy tissues [1-4]. Conventional hyperthermia in conjunction with radiation has demonstrated increased eectiveness in the treatment of certain types of cancer, such as those of liver metastases (the spread of a disease from one organ or part to another noncontiguous organ or part) [5-7]. Uniform temperature distributions are signicant to achieve and maintain during hyperthermia treatment [8] since the use of temperatures above 55°C may directly destroy tissues through thermal coagulation, as was illustrated by Beacco et al. [9]. For safety consideration in clinics, it is essential to ensure necrosis (the death of living cells or tissues) of the total tumor cells within the desired volume of treatment while minimizing the thermal damage to healthy tissues surrounding the tumor. Temperature variations, which may be associated with the mechanisms of heat removal by the body and inadequate heating technologies, are oen heterogeneous, and can lead to an undesired heating of the tissues, hot spots, and potential burning.
