ABSTRACT
Preload studies have shown that fat exerts the weakest effect on satiety compared to carbohydrate and protein, suggesting that fat may lead to “passive overconsumption” (Blundell et al., 1993). But when preloads were matched for energy density
and palatability, differences in satiety were not obvious (Geliebter, 1979; Stubbs and Harbron, 1996; McCrory et al., 2000), pointing to energy density as the key driver of satiety under experimental conditions. Furthermore, lipids suppress later food intake when present in the small intestine of both humans and animals (Welch et al., 1988; Greenberg et al., 1990; Drewe et al., 1992; Woltman and Reidelberger, 1995; Castiglione et al., 1998; Van Wymwlbeke et al., 1998).
