ABSTRACT
In recent years, an increasing number of genomes of model organisms have been sequenced. Using these genomic sequences, researchers have been able to make tremendous progress in the study of genomes, with numerous successes in the identification of genes, the detection of protein-binding DNA motifs, and the determination of gene regulation. Beyond these successes is the far more challenging and rewarding task of understanding proteomes by means of, e.g., (1) discovering signal transduction pathways, (2) determining protein structures, (3) detecting protein-protein, protein-DNA, and protein-metabolite interactions, (4) detecting post-translational modifications of proteins, and ultimately (5) elucidating the functions of genes and their protein products.
