ABSTRACT
ABSTRACT MicroRNAs (miRNAs) are short 19-25 nucleotide RNA molecules that have been shown to regulate the expression of other genes in a variety of eukaryotic systems. MiRNA alterations are involved in the initiation and progression of human cancers. Abnormal expression of miRNAs has been proved to be the main abnormality of the miRNoma in cancer cells. Various methods of microRNA expression profiling of human tumors, mainly by microarray, have identified signatures associated with diagnosis, progression, prognosis, and response to treatment.
