ABSTRACT

The goal of this chapter is to identify and prioritize species of animals that can serve as surrogates for environmental and human health in comparative toxicogenomics studies. By characterizing current research needs and by deriving a set of criteria for selecting appropriate surrogate species, we will accomplish this goal. These criteria will be applied in reviewing the species currently used in toxicological testing and research, ecological monitoring and research, and the genomic sciences. The review includes a short discussion on why a community-based approach is used (in one case) to promote a model species for this emerging field and will conclude by identifying a suite of species that could serve as an initial starting point for a multinational comparative toxicogenomics research program.