ABSTRACT
Abbreviations ................................................................................................................................. 655 25.1 Introduction .......................................................................................................................... 657 25.2 Angiogenesis ......................................................................................................................... 657
25.2.1 Denition and Process .............................................................................................. 657 25.2.2 Endogenous Mediators of Angiogenesis................................................................... 658
25.2.2.1 ECM Degradation ...................................................................................... 659 25.2.2.2 Activation of Endothelial Cells ..................................................................660 25.2.2.3 Cell Adhesion ............................................................................................. 661
25.2.3 Angiogenesis-Dependent Diseases and Therapy ...................................................... 661 25.2.3.1 Therapeutic Angiogenesis for Tissue Engineering .................................... 661 25.2.3.2 Anti-Angiogenesis Therapy and Cancer .................................................... 662
25.3 Polymeric Delivery Systems for Pro-and Anti-Angiogenic Therapy ..................................664 25.3.1 Ways of Targeting Angiogenic Sites .........................................................................664
