chapter  26
24 Pages

Bioceramics for Development of Bioarticial Liver

The cell culture carrier (scaffold) for loading cells into a column is the most important biomaterial for the construction of a bioarticial liver (BAL). Different kinds of materials are used for the construction of BALs of the extracorporeal and implant types. First, for the cases of a BAL of the extracorporeal type, the column volume necessary for human extracorporeal circulation is believed to be 100 mL at the minimum. BAL also has the role of a bioreactor for substance production, and should be available for the production of plasma proteins, physiologically active trace substances such as G-CSF and erythropoietin, and vaccines. The industrial bioreactor for these purposes requires liters of column volume, thus the scaffold used for lling the column should be rigid and have sufcient

26.1 Introduction .......................................................................................................................... 691 26.2 Biomaterials for the Development of Bioarticial Liver ......................................................692