chapter  10
36 Pages

Chapter Delivering the Bullet to the Right Intracellular Target: A Cellular Perspective on Drug Delivery

With the advent of genome sequencing and the tremendous success of reductionist approaches in molecular cell biology aimed at understanding the nature of complex systems in terms of interactions of their components, we now have gained immensely detailed knowledge of membrane trafcking, i.e., the ux of vesicular carriers and their contents between subcellular compartments such as the endoplasmic reticulum (ER), Golgi apparatus (GA), endosomes, and the

10.1 Introduction .......................................................................................................................... 219 10.2 Rational Intracellular Drug Delivery Knowing the Individual System ...............................220