ABSTRACT
Paclitaxel is a taxoid. It is a novel antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilizes them by preventing depolymerization. This stability inhibits the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, paclitaxel induces abnormal arrays or bundles of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis, further disrupting cell function.
