ABSTRACT
Internal radionuclide dosimetry from unsealed sources of radioactivity has always been a challenge. The practical implementations of this formalism—the Medical Internal Radiation Dose (MIRD) Pamphlet and the comparable MIRDOSE program—were based around the construction of a geometric phantom that approximated the average dimensions and locations of human organs. The dosimetry solutions divided into three general approaches: convolution, adaptation of the existing MIRD paradigm, and reinventing the wheel under a more general guise. MABDOSE was developed as both an extension of the MIRD philosophy and as a software program to implement that philosophy. The foundation of the MABDOSE program is the concept of the target lattice. The majority of an internal radionuclide dose estimate deals with manipulating data into a form that is usable by other program components. The desire to use radiolabeled antibodies in a therapeutic modality, however, placed an entirely new demand on the dosimetry community.
