ABSTRACT
Congenital central hypoventilation syndrome (CCHS) was first described by
Mellins in 1970 (1). Now, more than 30 years later, approximately 300 to
350 patients with CCHS have been reported (2-28). Moreover, late-onset
central hypoventilation syndrome (LO-CHS) has been recognized as a respira-
tory control disorder that manifests only in late infancy or childhood (20,29), or
even in adulthood (30,31).