ABSTRACT

Congenital central hypoventilation syndrome (CCHS) was first described by

Mellins in 1970 (1). Now, more than 30 years later, approximately 300 to

350 patients with CCHS have been reported (2-28). Moreover, late-onset

central hypoventilation syndrome (LO-CHS) has been recognized as a respira-

tory control disorder that manifests only in late infancy or childhood (20,29), or

even in adulthood (30,31).