ABSTRACT
The endocannabinoid system has emerged as an important modulator of neuronal functions, as demonstrated by the abundance of CB1 receptor in the brain (1). One of the key functions attributed to the endocannabinoid system in the brain is the control of food intake resulting in a significant orexigenic stimulus. However, more recently, the finding of a peripheral presence of CB1 receptor in many organs, involved in the regulation of metabolism, has changed the past identification of the endocannabinoid system as a particular neuronal orexigenic promoter, and its role in the regulation of energy balance has started to be completely re-evaluated (2-3).
