ABSTRACT
Obesity, insulin resistance, and dysglycemia are common features in patients with systemic hypertension. Even if the relationship between these leading factors of cardiovascular disease is well known, the pathophysiology linking these features is not clear. Review of evidence from epidemiological and experimental studies, emphasizing a link between these three determinants of cardio-metabolic abnormalities, suggests that obesity (particularly abdominal obesity) may play a “central” role in the association between insulin resistance and systemic hypertension.
